The Science
of Exercise Physiology
There are three steps involved in cellular respiration; the conversion
of food sources to energy:
1. Glycolysis: the breaking down of glucose molecules from carbohydrates
into molecules of pyruvate, which can be used in the following
stage the cytric acid cycle. This process occurs in the cytosol
of the cell and can proceed regardless of the presence of oxygen.
2. The Cytric Acid Cycle:
As pyruvate is being shuttled from the cytosol to the interior
of the mitochondrion, a microenzyme removes one carbon and two
oxygens from each molecule, producing Aceytl CoA. The Cytric acid
cycle is an aerobic process, meaning it needs oxygen to function.
3. The Electron Transport Chain:
Very little energy has been produced during glycolysis and the
Cytric acid. Most of the energy locked in the original glucose
molecule will be released by the electron transport chain and oxidative
phosphorylation. The electron transport chain is a network of electron-carrying
proteins. Therefore, the electron transport chain produces a gradient
through which ATP can be made known as chemiosmosis.
ATP
ATP is produced in the mitochondria by an enzyme called ATP Synthase.
ATP Synthase is powered by a transmembrane electrochemical
potential gradient in a process called the electron transport
chain. The function of the electron transport chain is to produce
this gradient. In all living organisms, a series of reduction
reactions (chemical reactions in which electrons are transferred
from one molecule to another) are used to produce a transmembrane
electrochemical potential gradient.
Adenosine triphosphate (ATP) is the source of energy for all
muscle contractions. Energy is released when ATP is broken into
ADP+Pi (adenosine diphosphate and phosphate group). Maintaining
the availability of ATP for muscle contraction is the limiting
factor for muscle performance since ATP is not stored in large
amounts in skeletal muscle. Sources of ATP come from both anaerobic
(does not require oxygen) and aerobic (requires oxygen). The
primary energy source for a given level of activity will depend
on the intensity of muscle contractions.
ATP energises the muscle contraction process by the ATPase activity
of the exposed myosin head. When ATP is exposed to the myosin
head, it is cleaved and energy is released. In addition to ATP,
magnesium is very necessary in ATP energy releasing reactions.
Before ATP can become active ATP magnesium must bind between
the second and third phosphate. Clinically, magnesium deficiency
may be related to such conditions as fibromyalgia and chronic
fatigue syndrome.
The synthesis of almost any chemical compound requires energy.
That energy is ATP, which is critically important to the biosynthesis
of proteins, phospholipids, purines, pyrimidines and many other
substances.
ATP is necessary for nerve transmission. Nerve transmission entails
the release of nerve transmitter substance from the pre-synaptic
terminal into the synaptic cleft, which is a space between one
nerve ending and another. The neurotransmitter spans the cleft
and attaches to the receptor of the other cell. The nerve transmitter
substance must be constantly renewed in the presynaptic terminal
for future release; the energy for this formation is supplied
by ATP. There are many mitochondria in the pre-synaptic terminal
to form and store the ATP for this process. At the post-synaptic
terminal, the next nerve cell down the line, it is through active
transport of sodium, potassium and calcium that concentration
differences across the nerve cell membrane cause nerve firing
and propagation of nerve signals to travel to the next presynaptic
terminal. These concentration gradients could not be accomplished
without ATPase active transport across nerve cell membranes. |